• Profile

Pretreatment peripheral blood leukocytes are independent predictors of survival in oral cavity cancer

Cancer Dec 13, 2019

Valero C, Zanoni DK, McGill MR, et al. - In an independent cohort of 1,369 oral cavity squamous cell carcinoma (OSCC) patients, researchers studied peripheral blood leukocytes (PBLs) as predictors of outcomes in OSCC and identified specific cutoffs with the objective of involving PBLs as host factor in the preoperative risk assessment of patients. Previously established head and neck squamous cell carcinoma (HNSCC) cutoffs have been analyzed. Then optimal OSCC cutoffs from the external HNSCC cohort were found and validated in the subset of OSCC patients. Using the previous cutoffs, all parameters were significant predictors of survival. OSCC cutoffs, however, have better-stratified survival outcomes. The most robust independent predictors of overall survival among all PBLs in OSCC were pretreatment peripheral blood neutrophils, neutrophil-to-lymphocyte ratio, and Systemic Inflammation Response Index. The investigators present externally validated cutoffs demonstrating the viability of including PBLs as host features in OSCC's preoperative prognosis.
Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free.
  • 55 lakhs+ doctors trust M3 globally

  • Nonloggedininfinity icon
    Unlimited access to original articles by experts
  • Nonloggedinlock icon
    Secure: we never sell your data
  • Signing up takes less than 2 mins
Try M3 India / Log In
M3 app logo
Choose easy access to M3 India from your mobile!

M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen