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FGF8, FGF10 and FGF receptor 2 in foreskin of children with hypospadias: An analysis of immunohistochemical expression patterns and gene transcription

Journal of Pediatric Urology Nov 19, 2019

Haid B, Pechriggl E, Nägele F, et al. - Skin samples from the ventrolateral aspect of the foreskin of 32 individuals with hypospadias (17 distal and 15 proximal) and ten normal foreskin samples were investigated by immunohistochemistry in order to examine expression patterns and transcription levels of FGF8, FGF10, and FGF Receptor 2 (FGFR2) in individuals with hypospadias vs normal controls. In comparisons of normal foreskin to the foreskin of individuals with hypospadias, notable variations in localization and distribution of FGF8, FGF10, and FGFR2 were noted, whilst no variation in the quantitative expression of these markers on the mRNA level was seen. This validated the notion that during the embryogenesis of hypospadias, penile skin is impacted by the embryological aberrations as well.
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