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Male age is more critical to sperm DNA integrity than routine semen parameters in Chinese infertile males

Andrologia Nov 07, 2019

Guo LY, et al. - In this retrospective study, experts assessed the association between the sperm DNA integrity results and infertile male age or sperm motility in 654 infertile men who underwent infertility assessment from 2013 to 2016. According to age (≤ 30, 30–35 and ≥ 35), men with normozoospermia or abnormal semen parameters were classified into groups 1, 2 and 3, or groups A, B, and C, respectively. In groups 3 and C among their respective cohorts, the sperm DNA fragmentation index (DFI) and DFI abnormality rates were highest. However, within the same age range, they were not significantly distinct among groups. Between persons with normal DFIs and those with abnormal DFIs in group C, but not in group 3, statistically important variations in male age, progressive motility, and total motility were discovered. Irrespective of conventional semen parameters, elderly (≥ 35 years) infertile men have raised sperm DNA fragmentation. Compared with routine semen parameters, the male age is more crucial to sperm DNA integrity.
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