• Profile
Close

Clinical correlates of sex steroids and gonadotropins in men over the late adulthood: The Framingham Heart Study

International Journal of Andrology Nov 01, 2019

Haring R, Xanthakis V, Coviello A, et al. - Among older men included in the original cohort of the Framingham Heart Study, researchers investigated the short- (2-years; 1,165 person-observations in 528 people) as well as long-term (up to 10-years follow-up; 2520 person-observations in 835 people with mean baseline age: 71.2 years) clinical correlates of sex steroids and gonadotropins [total testosterone (TT), dehydroepiandrosterone sulphate (DHEAS), follicle stimulating hormone (FSH), luteinizing hormone (LH) and total estradiol], employing multilevel modelling and Generalized Estimating Equations. They found an inverse link of age, body mass index and pre-existing type 2 diabetes, with long-term TT levels, whereas a positive link was displayed by higher systolic blood pressure. They also observed inverse link of age and pre-existing cardiovascular disease (CVD) with long-term DHEAS levels, and positive link of HDL cholesterol levels with long-term DHEAS levels. An inverse link of age with DHEAS but a positive association with FSH and LH levels were also revealed in analyses of short-term changes. Correlates of decreasing TT and DHEAS levels in elderly men were identified, which were modifiable. This implies that the age-associated fall of these hormones over late adulthood may be alleviated by maintaining a low CVD risk factor burden.
Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
  • Exclusive Write-ups & Webinars by KOLs

  • Nonloggedininfinity icon
    Daily Quiz by specialty
  • Nonloggedinlock icon
    Paid Market Research Surveys
  • Case discussions, News & Journals' summaries
Sign-up / Log In
x
M3 app logo
Choose easy access to M3 India from your mobile!


M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen
Okay