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Bilateral is superior to unilateral varicocelectomy in infertile men with bilateral varicocele: Systematic review and meta-analysis

Andrologia Oct 30, 2019

Ou N, Zhu J, Zhang W, et al. - Researchers conducted this systematic review and meta-analysis to ascertain if bilateral surgery may bring more benefits to infertile patients with bilateral varicocele vs unilateral surgery. To identify studies published in English that used varicocelectomy, a search of PubMed, Web of Science, EMBASE and the Cochrane Library on January 13, 2019, was conducted. A total of 11 articles with a total of 1,743 patients were finally registered. For patients with bilateral varicocelectomy, spontaneous pregnancy rates were higher than unilateral varicocelectomy with an odds ratio of 1.89. The findings showed bilateral is superior to unilateral varicocelectomy concerning sperm concentration, sperm motility, the progression of sperm motility and sperm morphology between bilateral and unilateral varicocelectomy. In infertile males with bilateral varicocele (both left clinical and right subclinical varicocele and bilateral clinical varicocele), bilateral varicocelectomy may be superior to unilateral in terms of spontaneous pregnancy rate and sperm motility.
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