• Profile
Close

Circulating advanced glycation endproducts and long-term risk of cardiovascular mortality in kidney transplant recipients

Clinical Journal of the American Society of Nephrology Oct 14, 2019

Sotomayor CG, Gomes-Neto AW, van Londen M, et al. - In this prospective cohort analysis, researchers examined the link of advanced glycation endproducts (AGEs) (ie, Nε-[Carboxymethyl]lysine (CML) and Nε-[Carboxyethyl]lysine (CEL), measured by tandem mass spectrometry) with cardiovascular mortality among stable kidney transplant recipients. Whether inflammatory, oxidative stress and endothelial dysfunction biomarkers could mediate this link was also inquired. This study included 555 kidney transplant recipients of age 51 ± 12 years, 56% were men. Findings revealed independent association of circulating levels of AGEs with long-term risk of cardiovascular mortality in the participants. Nearly 35% of the link of CML and CEL with cardiovascular mortality was consistently explained by free thiol groups and soluble vascular cell adhesion molecule-1, as revealed in mediation analyses.
Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
  • Exclusive Write-ups & Webinars by KOLs

  • Nonloggedininfinity icon
    Daily Quiz by specialty
  • Nonloggedinlock icon
    Paid Market Research Surveys
  • Case discussions, News & Journals' summaries
Sign-up / Log In
x
M3 app logo
Choose easy access to M3 India from your mobile!


M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen
Okay