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Characterization of the microstructure of the intervertebral disc in patients with chronic low back pain by diffusion kurtosis imaging

European Spine Journal Aug 20, 2019

Li L, Zhou Z, Xiong W, et al. - A total of 30 patients with chronic non-specific low back pain (CLBP) and 23 asymptomatic controls (AC) underwent diffusion kurtosis imaging (DKI) of the lumbar spine with a 3T MRI scanner were recruited in a study by the experts in order to distinguish CLBP individuals and AC. Between CLBP and AC groups, no variation in the T2 grades, ADC value, and multiple parameters in DKI of NP was noted. The average FA values in NP in the AC group vs CLBP group were significantly greater. With 90% of sensitivity and 70% specificity, the scores for the intactness of AF of the intervertebral discs were significantly distinctive in CLBP and AC groups. Moreover, notable variations in the length and volume values of the AF in CLBP and AC groups was observed. Thus, DKI was concluded as a good noninvasive method, and it may help to distinguish CLBP from AC. Especially, the continuation of DKI tractography highlighted the presence of annulus fibrosus fissures which is a significant character in the generation of the low back pain.
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