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A novel role for GATA3 in mesangial cells in glomerular development and injury

Journal of the American Society of Nephrology Aug 17, 2019

Grigorieva IV, Oszwald A, Grigorieva EF, et al. - Researchers investigated the role of GATA3, a dual-zinc finger transcription factor that regulates gene expression in many developing tissues, in glomerular development or injury. For this purpose, they took developing and mature kidneys from Gata3 heterozygous (+/−) knockout mice, as well as injured human and rodent kidneys, and evaluated GATA3 expression in these. FOXD1 lineage stromal progenitor cells expressed GATA3, and maturation of a subset of these cells into mesangial cells (MCs) that continue to express GATA3 in adult kidneys was observed. GATA3 was found necessary for normal glomerular development in mice. GATA3 expression was maintained in MCs of adult kidneys and was found to be markedly elevated in rodent models of mesangioproliferative GN and in IgA nephropathy. This implies an important role of GATA3 in the maintenance of glomerular homeostasis. Based on these findings, GATA3 was viewed as a possible new and robust nuclear marker for identifying MCs in tissue sections.
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