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Ideal cardiovascular health metrics and major cardiovascular events in patients with prediabetes and diabetes

JAMA Aug 05, 2019

Wang T, Lu J, Su Q, et al. - Via performing a cohort study that included a sample of 111,765 Chinese individuals, researchers examined the correlations of ideal cardiovascular health metrics (ICVHMs) with subsequent development of cardiovascular disease (CVD) among individuals with prediabetes or diabetes vs individuals with normal glucose regulation. According to findings, 24,881, 61,024, and 25,860 individuals, had normal glucose regulation, prediabetes, and diabetes, respectively. Among individuals with prediabetes, the multivariable-adjusted HR for CVD was 1.34 for individuals who had 1 ICVHM or less, and 0.57 for individuals who had ≥ 5 ICVHMs, compared with individuals with normal glucose regulation. The HRs for CVD were 2.05 and 0.80 for individuals who had 1 ICVHM or less and ≥ 5 ICVHMs, respectively, amongst individuals with diabetes. For individuals younger than 55 years of age, such a pattern of correlation between ICVHM and CVD was more prominent, in comparison with individuals 65 years or older. Moreover, the HR for CVD per additional ICVHM was 0.82 and 0.85 among individuals with prediabetes and among individuals with diabetes, respectively. Therefore, lower or no significant excess CVD risks was demonstrated by individuals with prediabetes or diabetes who had ≥ 5 ICVHMs vs with normal glucose regulation.

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