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Longitudinal changes in bone density in adolescents and young adults with cerebral palsy: A case for early intervention

Clinical Endocrinology Jul 03, 2019

Trinh A, et al. - In people with cerebral palsy (CP), researchers evaluated changes in areal bone mineral density (aBMD) during adolescence and young adulthood. Between 2006 and 2018, 45 patients with CP who had longitudinal dual-energy x-ray absorptiometry (DXA) scans at a single tertiary hospital were included. Data revealed that the median change in aBMD was +1.2-1.9%/year in all patients; in those <20 years of age, the median change was 4-8%/year. According to this retrospective longitudinal study, low bone mass was evident from the baseline DXA in adolescents with CP. During the second decade, however, significant bone accrual occurred, followed by bone maintenance at young adulthood. The reduced functional state as measured by the gross motor functional classification scale had a slightly negative effect over time on aBMD.

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