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Association between liver fibrosis and serum prostate specific antigen (PSA) among US men: National Health and Nutrition Examination Survey (NHANES) 2001-2010

Cancer Epidemiology, Biomarkers & Prevention Jun 08, 2019

Wang A, et al. - Researchers used data from the NHANES (2001-2010) to assess the link between liver fibrosis scores and PSA level among US adult men overall and by race/ethnicity. Overall 6,705 men, aged 40 years, without a prostate cancer diagnosis, having measured serum PSA, liver enzymes, albumin, and platelet counts as part of NHANES protocol, were included. Three scores: AST to platelet ratio index, fibrosis 4 index and NAFLD fibrosis score, were used to measure liver fibrosis. According to the findings, lower serum PSA was present in men with higher liver fibrosis scores across all race/ethnicities. Lower odds of an elevated PSA was observed in men with advanced fibrosis scores.
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