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A fully magnetically levitated left ventricular assist device — Final report

New England Journal of Medicine Mar 22, 2019

Mehra MR, et al. - In two interim analyses of this trial, patients with advanced heart failure treated with a fully magnetically levitated centrifugal-flow left ventricular assist device were less likely than patients treated with a mechanical-bearing axial-flow left ventricular assist device to have pump thrombosis or nondisabling stroke, researchers compared a centrifugal-flow left ventricular assist device with an axial-flow device in advanced-stage heart failure patients. In the centrifugal-flow pump group, the number of events per patient-year for any severity stroke, major bleeding, and gastrointestinal hemorrhage was lower than in the axial-flow pump group. Among 1,028 patients with advanced heart failure, a fully magnetically levitated centrifugal-flow left ventricular assist device was related to a less frequent need for pump replacement vs an axial-flow device and was superior in terms of replacing or removing a malfunctioning device and survival free of disabling stroke or reoperation.

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