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Low serum creatinine and risk of diabetes: The Japan Epidemiology Collaboration on Occupational Health Study

Journal of Diabetes Investigation Mar 21, 2019

Hu H, et al. - Researchers estimated 31,343 male workers without diabetes of age between 20 and 64 years old to assess the relationship between serum creatinine levels and diabetes (either HbA1c levels ≥6.5%, random glucose levels ≥200 mg/dL, fasting glucose levels ≥126 mg/dL, or receiving antidiabetic treatment). They observed that 2509 cases had developed diabetes with a median observation of 7.7 years. They reported a correlation between lower cumulative average serum creatinine levels and a greater risk of diabetes after adjusting for age, smoking, body mass index, hypertension, and dyslipidemia. They more prominently noticed serum creatinine-diabetes association among older adults (serum creatinine <0.70 vs 0.90-1.20 mg/dL) as compared to younger adults.
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