New indicator may predict prognosis in renal cancer
M3 Global Newsdesk Mar 23, 2018
The acetyl-CoA synthetase (ACSS2) protein is highly expressed in renal cell carcinoma (RCC) and is indicative of a poor prognosis, according to a study published in Urologic Oncology.
A considerable proportion of RCC cases have high expression of ACSS2 protein, suggesting the relationship of high-ACSS2 expression and poor prognosis in RCC.
The retrospective study was designed to investigate ACSS2 expression and the relationship to survival in patients with RCC. It was led by Shaojin Zhang, MD, from Zhengzhou University in Henan Province, China.
Results are conflicting regarding the role of mitochondrial ACSS2 expression and its function in cancer. Prior research has shown that in breast cancer and glioblastoma, ACSS2 knockdown inhibits tumor growth in vivo. In addition, ACSS2 overexpression contributes to aggressive growth and worse prognosis.
