• Profile
Close

Putting the brakes on our immune system

ScienceDaily Mar 07, 2019

Researchers have discovered how a tiny molecule known as miR-132 acts as a "handbrake" on our immune system—helping us fight infection. The scientists say the findings could lead to new treatments for life-threatening infections such a leishmaniasis, as well as autoimmune and chronic inflammatory diseases.

Our immune system protects us from invading pathogens, but also has the capacity to overreact, causing irreparable damage to our own tissue. When fighting a long-lived infection, the spleen can become bigger as it attacks the invader.

Although this is necessary for an effective immune response, if the spleen becomes too big, as occurs in some infections, this can stop the immune system from working properly, leading to serious clinical complications and even death.

A study funded by the Medical Research Council, led by researchers at the University of York, and carried out in collaboration with Queen Mary University London, discovered a novel mechanism that specifically promotes immune responses to protect from infection.

At the heart of it all is a tiny part of our genome named miR-132. This belongs to a family of genes called microRNAs. The research revealed that miR-132 controls how immune cells respond to infection. In a pre-clinical model of visceral leishmaniasis (a fatal parasitic disease) lack of miR-132 limits spleen enlargement but also the immune response. This leads to increased susceptibility to infection.

The team discovered that although miR-132 is not a protein itself, it masters activation of immune cells by harnessing the protein-making super engines of the cell called ribosomes. Through pacing these "enthusiastic engines," miR-132 ensures that immune responses persist as long as is required for optimal parasite clearance.

Dr. Dimitris Lagos, senior lecturer in immunology at Hull York Medical School, University of York said, "When you are responding to an infection, your immune system protects you and keeps you alive, but it can also be the thing that makes you ill, and getting that balance wrong is what usually leads to a chronic infection."

"We looked at which molecules help you and, in particular, the role of the miR-132. It is a very small part of your DNA, but we discovered that it helps control how others molecules work. It acts as a pacer, making sure your immune system doesn't go too fast and get exhausted. It seems like, in this case, driving with a handbrake on is the way our body protects us from infection."

"This discovery opens novel routes of clinical intervention that aim to promote protective immunity and limit damage in life-threatening infections." Researchers say the next stage will be to develop drugs that promote the beneficial effects of miR-132 in the immune system. The findings are published in the journal EMBO Reports.

Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
  • Exclusive Write-ups & Webinars by KOLs

  • Nonloggedininfinity icon
    Daily Quiz by specialty
  • Nonloggedinlock icon
    Paid Market Research Surveys
  • Case discussions, News & Journals' summaries
Sign-up / Log In
x
M3 app logo
Choose easy access to M3 India from your mobile!


M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen
Okay